Thelansis

 Type 2 diabetes is a chronic and progressive metabolic disorder, typically irreversible, characterized by impaired metabolism of carbohydrates, fats, and proteins due to insufficient or ineffective use of the hormone insulin. Three core pathophysiological processes contribute to the development of type 2 diabetes: insulin resistance, defective insulin secretion, and excessive hepatic glucose production. This results in hyperglycemia, prompting increased insulin production, followed by a decline in the function and mass of pancreatic beta cells, ultimately leading to diabetes. In the majority of diabetic and prediabetic individuals, a high body mass index (BMI > 30) is a crucial predisposing factor for the onset of type 2 diabetes. There is a close association between the prevalence of insulin resistance and obesity. Vascular inflammation arising from hyperglycemia plays a pivotal role in the emergence of complications during late-stage diabetes, affecting both macro- and microv...

  Type 2 diabetes is a chronic progressive metabolic disorder, usually irreversible, that leads to impaired metabolism of carbohydrates, fats, and proteins because of a lack of, or ineffective use of, the hormone insulin. Three core pathophysiological processes combine to produce type 2 diabetes: insulin resistance, defective insulin secretion, and excess hepatic glucose production. The resulting hyperglycemia leads to excess insulin production, followed by a decline in the function and mass of pancreatic beta cells, leading to diabetes. For most diabetic and prediabetic patients, a high BMI (> 30) is the predetermining etiological factor for developing type 2 diabetes. A close link exists between the prevalence of insulin resistance and obesity. Vascular inflammation resulting from hyperglycemia is a critical factor in the emergence of complications in late-stage diabetes. Both macro- and microvasculature are affected, leading to retinopathy, neuropathy, nephropathy, and cardio...

Type 2 diabetes is a chronic progressive metabolic disorder, usually irreversible, that leads to impaired metabolism of carbohydrates, fats, and proteins because of a lack of, or ineffective use of, the hormone insulin. Three core pathophysiological processes combine to produce type 2 diabetes: insulin resistance, defective insulin secretion, and excess hepatic glucose production. The resulting hyperglycemia leads to excess insulin production, followed by a decline in the function and mass of pancreatic beta cells, leading to diabetes. For most diabetic and prediabetic patients, a high BMI (> 30) is the predetermining etiological factor for developing type 2 diabetes. A close link exists between the prevalence of insulin resistance and obesity. Vascular inflammation resulting from hyperglycemia is a critical factor in the emergence of complications in late-stage diabetes. Both macro- and microvasculature are affected, leading to retinopathy, neuropathy, nephropathy, and cardiovascul...