Thelansis

  Chronic myeloid leukemia (CML) is also known as chronic myelogenous leukemia. It's a type of cancer that starts in certain blood-forming cells of the bone marrow. In CML, a genetic change takes place in an early (immature) version of myeloid cells -- the cells that make red blood cells, platelets, and most types of white blood cells (except lymphocytes). This change forms an abnormal gene called BCR-ABL, which turns the cell into a CML cell. The leukemia cells grow and divide, building up in the bone marrow and spilling over into the blood. In time, the cells can also settle in other parts of the body, including the spleen. CML is fairly slow-growing leukemia, but it can change into fast-growing acute leukemia that's hard to treat. Morphologically, CML is characterized by the hypercellular bone marrow, unregulated growth of myeloid cells (neutrophils, eosinophils, basophils, and megakaryocytes) resulting in an abnormally high level of morphologically terminally differentiated...