Thelansis

  Neurofibromas are benign nerve sheath tumors composed of differentiated neoplastic Schwann cells and a mixture of nonneoplastic components. These tumors can present as nodular and well-demarcated or diffuse growths. Intraneural neurofibromas typically grow along the nerve confined within its epineurium. The main cellular constituents of neurofibromas are neoplastic Schwann cells, characterized by small, curved, or elongated nuclei, along with fibroblasts embedded within a myxoid/collagenic matrix in varying proportions. While neurofibromas may exhibit focal resemblance to Antoni B pattern, they lack Antoni A pattern and hyalinized blood vessels, distinguishing them from schwannomas. The Schwann cell component in neurofibromas shows expression of S100 and SOX10 proteins. Both sporadic and syndromic neurofibromas are associated with a deletion in the NF1 gene. Sporadic cases only involve the lesional cells carrying the NF1 mutation, while syndromic cases result from a germline mu...

 Neurofibromas are benign nerve sheath tumors composed of differentiated neoplastic Schwann cells and a mixture of nonneoplastic components. These tumors can present as nodular and well-demarcated or diffuse growths. Intraneural neurofibromas typically grow along the nerve confined within its epineurium. The main cellular constituents of neurofibromas are neoplastic Schwann cells, characterized by small, curved, or elongated nuclei, along with fibroblasts embedded within a myxoid/collagenic matrix in varying proportions. While neurofibromas may exhibit focal resemblance to Antoni B pattern, they lack Antoni A pattern and hyalinized blood vessels, distinguishing them from schwannomas. The Schwann cell component in neurofibromas shows expression of S100 and SOX10 proteins. Both sporadic and syndromic neurofibromas are associated with a deletion in the NF1 gene. Sporadic cases only involve the lesional cells carrying the NF1 mutation, while syndromic cases result from a germline mutat...