Thelansis

  Methamphetamine use disorder refers to the illicit use of methamphetamines as a drug of abuse. It is a cationic lipophilic molecule that stimulates the release, and partially blocks the reuptake, of newly synthesized catecholamines in the CNS (Cho and Melega, 2002). Due to its structural similarity, methamphetamine substitutes for the dopamine transporter (DAT), noradrenaline transporter (NET), serotonin transporter (SERT), and vesicular monoamine transporter-2 (VMAT-2) and reverses their endogenous function, thereby redistributing monoamines from storage vesicles into the cytosol. Further, the majority of individuals admitted to treatment were non-Hispanic White (69%), followed by individuals of Mexican origin.   Methamphetamine dependence is largely a disorder of the White population; however, this may be a byproduct of the regional variability in methamphetamine use, which is currently greatest in the West and parts of the Midwest. The rates of methamphetamine depen...