Thelansis

  Ulcerative colitis is a chronic inflammatory bowel disease that can negatively impact the growth, nutritional well-being, and psychosocial development of affected children. Approximately 25% of individuals diagnosed with inflammatory bowel disease (IBD) are under 18. Children and adolescents with ulcerative colitis often experience a more severe disease course, more extensive intestinal involvement at diagnosis, and faster disease progression than adults. It is not uncommon for pediatric patients to present with atypical symptoms. Typical symptoms of pediatric ulcerative colitis include abdominal pain, chronic diarrhea, sometimes with blood, weight loss, fatigue, fever, and rectal bleeding. The clinical presentation of the disease is closely linked to its location and the extent of inflammation. In terms of disease extent, it is categorized into four groups: ulcerative proctitis (E1), left-sided UC (E2), extensive UC (E3), and pancolitis (E4). Disease severity is classified as ...

  Indication name: Ulcerative Colitis (UC) Ulcerative colitis is a chronic inflammatory condition affecting the rectal and colonic mucosa and submucosa. In over 95% of cases, the inflammation primarily targets the rectum and then spreads contiguously. Characteristic microscopic features of ulcerative colitis include crypt abscesses leading to mucosal ulceration, often accompanied by undermining adjacent mucosal tissue. Mucosal bridging and pseudopolyp formation frequently occur in a circular pattern. In contrast, granulomatous colitis typically displays linear ulcerations on the colonic lumen's mesenteric side. Differential diagnosis for ulcerative colitis encompasses Crohn's disease and infectious colitis caused by pathogens like bacteria, viruses, or parasites. Ulcerative colitis typically manifests as continuous inflammation, while Crohn's disease may exhibit patches of healthy mucosa between affected areas. It's also essential to differentiate ulcerative colitis ...