Thelansis

  Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal condition that regurgitates stomach contents into the esophagus. Various mechanisms cause it, some intrinsic and some structural, to disrupt the barrier at the esophagogastric junction, exposing the esophagus to acidic gastric contents. Clinically, GERD commonly presents with symptoms like heartburn and regurgitation. However, it can manifest atypically with extra-esophageal symptoms such as chest pain, dental erosion, chronic cough, laryngitis, or asthma. GERD is categorized into three phenotypes based on endoscopic and histopathologic findings: non-erosive reflux disease (NERD), erosive esophagitis (EE), and Barrett's esophagus (BE). Individuals with asthma face a higher risk of developing GERD. Asthma exacerbations can relax the lower esophageal sphincter, allowing stomach contents to reflux into the esophagus. Some asthma medications, particularly theophylline, may exacerbate reflux symptoms. Various diagn...

  Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal condition that regurgitates stomach contents into the esophagus. Various mechanisms cause it, some intrinsic and some structural, to disrupt the barrier at the esophagogastric junction, exposing the esophagus to acidic gastric contents. Clinically, GERD commonly presents with symptoms like heartburn and regurgitation. However, it can manifest atypically with extra-esophageal symptoms such as chest pain, dental erosion, chronic cough, laryngitis, or asthma. GERD is categorized into three phenotypes based on endoscopic and histopathologic findings: non-erosive reflux disease (NERD), erosive esophagitis (EE), and Barrett's esophagus (BE). Individuals with asthma face a higher risk of developing GERD. Asthma exacerbations can relax the lower esophageal sphincter, allowing stomach contents to reflux into the esophagus. Some asthma medications, particularly theophylline, may exacerbate reflux symptoms. Various diagn...