Thelansis

  Acute lymphoblastic leukemia (ALL) is a malignant proliferation of lymphoid cells blocked at an early stage of differentiation that can invade the bone marrow, blood, and extramedullary sites. Although most acute lymphoblastic leukemia arises in healthy individuals, inherited genetic susceptibility and environmental risk factors have been identified in some patients. Several genetic syndromes have been identified in the pediatric population that predispose individuals to acute lymphoblastic leukemia. Common allelic variants have increased disease susceptibility with an additive effect. They are categorized into B-cell and T-cell acute lymphoblastic leukemia, characterized by chromosomal abnormalities and genetic alterations involved in the differentiation and proliferation of lymphoid precursor cells. Along with response to treatment, these abnormalities are important prognostic factors. Most ALL cases occur in children, and most deaths from ALL occur in adults. Children may do b...