Thelansis

 Familial amyloid polyneuropathy (FAP) is a neurodegenerative condition characterized by the abnormal accumulation of mutant transthyretin (TTR) amyloid fibrils outside of cells, primarily in the peripheral nervous system. Mutations in the TTR gene lead to the destabilization of the TTR protein, causing it to change from its normal tetrameric form into a form that can form amyloid fibrils. In countries where FAP is prevalent, it typically manifests as small fiber neuropathy that varies in severity based on the length of the affected nerves. There are several distinct types of FAP, such as the Portuguese, Japanese, and Swedish variants. While they share similar clinical characteristics, they differ in the age at which symptoms typically appear. For instance, Portuguese FAP can begin in a person's third or fourth decade, Japanese FAP typically emerges between ages 25 and 35, and Swedish FAP tends to start after age 55. Despite these differences, all three types share the underlying b...