Thelansis

  Acquired fibrinogen deficiency (AFD), often linked with significant blood loss, presents a recurrent challenge in critical care scenarios. Fibrinogen plays a pivotal role in clot formation, as a crucial protein for initiating and maintaining coagulation. Typically, normal fibrinogen levels range from 1.5 to 4.5 g/l, with increases observed during pregnancy. However, fibrinogen is notably the first clotting factor to decrease to critically low levels in cases of severe bleeding. Moreover, significant blood loss can exhaust the body's fibrinogen reserves. Conditions such as circulatory shock, certain carcinomas (e.g., prostate cancer), or sepsis can lead to excessive fibrinogen consumption, resulting in continuous clot formation and depletion of coagulation factors, ultimately leading to fibrinogen deficiency. Instances of low fibrinogen levels due to high fibrinogen usage are commonly associated with profuse bleeding or trauma during surgical procedures or accidents. Hypofibrino...