Thelansis

 Wolfram syndrome, also referred to as DIDMOAD, is a hereditary condition commonly characterized by childhood-onset insulin-dependent diabetes mellitus and progressive optic atrophy. It is caused by mutations in two genes: WFS1 (4p16.1) and CISD2 (4q24). WFS1 produces Wolframin, a protein in the endoplasmic reticulum (ER) that maintains calcium levels and responds to unfolded proteins. Mutations in WFS1 are primarily responsible for most Wolfram syndrome symptoms, defining WS1. CISD2, on the other hand, encodes the ERIS protein, which moves dynamically between the ER and the outer membrane of mitochondria, regulating glucose homeostasis, insulin sensitivity, calcium balance, and autophagy. Mutations in CISD2 lead to WS2. Common symptoms of Wolfram syndrome encompass diabetes mellitus, optic nerve deterioration, central diabetes insipidus, sensorineural hearing loss, urinary tract issues, and progressive neurological challenges. Diabetes mellitus is the initial sign, often diagnosed...

 Wolfram syndrome, also known by the acronym DIDMOAD, is an inherited condition typically associated with childhood-onset insulin-dependent diabetes mellitus and progressive optic atrophy. In addition, many people with Wolfram syndrome also develop diabetes insipidus and sensorineural hearing loss. ·        1 in 500,000 people worldwide is thought to have Wolfram syndrome type 1. There have been about 200 cases reported in the scientific literature. Only a small number of Jordanian families have been identified as having Wolfram syndrome type 2. Thelansis’s “Wolfram Syndrome Market Outlook, Epidemiology , Competitive Landscape , and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Wolfram Syndrome treatment modalities opt...

Wolfram syndrome, also known by the acronym DIDMOAD, is an inherited condition typically associated with childhood-onset insulin-dependent diabetes mellitus and progressive optic atrophy. In addition, many people with Wolfram syndrome also develop diabetes insipidus and sensorineural hearing loss. Etiology- The two types of Wolfram syndrome (type 1 and type 2) are primarily differentiated by their genetic cause.  Variations (mutations) in the WFS1 gene are responsible for about 90% of Wolfram syndrome type 1 cases. This gene encodes wolframin, an essential protein for the endoplasmic reticulum's proper functioning (the part of a cell involved in protein production, processing, and transport). Wolframin helps regulate the amount of calcium in cells, which is essential for many different cellular functions. A specific mutation in the CISD2 gene causes Wolfram syndrome type 2. Although the exact function of this gene is not known, scientists suspect that it plays a vital role in the m...