Thelansis

 Granulomatosis with Polyangiitis (GPA) is a systemic vasculitis associated with ANCA (anti-neutrophil cytoplasmic antibody) primarily affecting the respiratory tract and kidneys. It can manifest at any age, with a higher occurrence between 65 and 74. The condition often presents with general constitutional symptoms such as fatigue, muscle pain, joint pain, reduced appetite, and weight loss. It affects various organs, but the upper airway and renal involvement are most common. In particular, upper airway involvement is characteristic, occurring in 70-100% of cases at the time of diagnosis. It typically manifests as issues in the nasal and sinus areas, including symptoms like nasal discharge, nosebleeds, nasal ulcers, perforation of the nasal septum, granulomatous lesions, or damage to facial cartilage leading to deformities in the nasal bridge, as well as inflammation in the sinuses or surrounding areas. ·        The annual incidence of Granulomatosi...

 Granulomatosis with Polyangiitis (GPA) is a systemic ANCA-associated granulomatous vasculitis whose lesions mainly affect the respiratory tract and kidneys. It can occur at any age, with a peak at 65-74 years of age. The disease can present with non-specific constitutional symptoms: malaise, myalgia, arthralgia, anorexia, and weight loss. It affects different organs, airways and renal involvement being the most frequent. The involvement of the upper airway is the most common and characteristic (70-100% at the time of diagnosis), mainly at the nasal and sinus levels, and may manifest with nasal discharge, epistaxis, nasal ulcers, perforation of the nasal septum, granulomatous lesions or destruction of facial cartilage with deformation of the nasal bridge, sinus or parasinus inflammation. ·        The annual incidence of Granulomatosis with Polyangiitis (GPA) ranges between 5 to 10 cases per million population, and the prevalence cases range between 5...

  Granulomatosis with Polyangiitis (GPA) is a systemic ANCA-associated granulomatous vasculitis whose lesions mainly affect the respiratory tract and kidneys. It can occur at any age with a peak at 65-74 years of age. The disease can present with non-specific constitutional symptoms: malaise, myalgia, arthralgia, anorexia, weight loss. It affects different organs, airways, and renal involvement being the most frequent. The involvement of the upper airway is the most common and characteristic (70-100% at the time of diagnosis), mainly at the nasal and sinus levels, and may manifest with nasal discharge, epistaxis, nasal ulcers, perforation of the nasal septum, granulomatous lesions or destruction of facial cartilage with deformation of the nasal bridge, sinus or parasinus inflammation. ·        The annual incidence cases range between 5 to 10 cases per MN population and the prevalence cases range between 56  to 89 cases per million. The competi...