Thelansis

 Natural killer (NK)/T-cell lymphomas are aggressive cancers that are classified as nasal, non-nasal, and disseminated subtypes. Nasal NK/T-cell lymphomas affect the nasal cavity as well as the upper aerodigestive tract. Skin, testis, gastrointestinal tract, and other extranodal sites are all affected by non-nasal NK/T-cell lymphomas. Disseminated NK/T-cell lymphoma affects multiple organs and rarely presents with a leukemic phase. CD3 (not surface CD3), cytotoxic molecules, CD56, and EBV-encoded small RNA are all found in lymphoma cells. Natural killer (NK) cells arise from a common lymphoid progenitor that can differentiate into all lymphoid lineages. Expression of the transcription regulators STAT5, RUNX3, NOTCH, PU.1, TCF1, NFIL3 and CBFB leads to NK lineage commitment. NK cells are part of the innate immune system and are responsible for detecting and killing tumours or virally infected cells. They are strategically located at mucosal surfaces, the skin and the gut and circula...