Thelansis

  Hypereosinophilic Syndrome (HES) is a group of disorders characterized by elevated blood eosinophil counts (>1.5 × 109/L) and resultant organ damage, commonly affecting the heart. Initially, the term referred to the combination of peripheral blood eosinophilia and tissue infiltrates leading to dysfunction or damage. Organ damage or dysfunction occurs due to eosinophils' release of cytotoxic substances, including eosinophil cationic protein, major basic protein, ribonuclease eosinophil derived neurotoxin, eosinophil peroxidase, and enzymes such as elastase and collagenase. Symptoms of HES can vary greatly among patients and include skin rashes, dizziness, memory loss, coughing, shortness of breath, fatigue, fever, and mouth sores. Classifying HES patients can be challenging and requires specialized laboratory evaluation. Predominant skin symptoms without heart involvement, along with serum hyper IgE or polyclonal hypergammaglobulinemia, may suggest the lymphocytic variant of ...

 Hypereosinophilic Syndrome (HES) is a group of disorders characterized by elevated blood eosinophil counts (>1.5 × 109/L) and resultant organ damage, commonly affecting the heart. Initially, the term referred to the combination of peripheral blood eosinophilia and tissue infiltrates leading to dysfunction or damage. The "idiopathic" label reflected the lack of knowledge regarding underlying causes, excluding known diseases such as drug allergies, parasitic infections, cancer, lymphoma and myeloproliferative disorders. Symptoms of HES can vary greatly among patients and include skin rashes, dizziness, memory loss, coughing, shortness of breath, fatigue, fever, and mouth sores. Organ damage or dysfunction occurs due to the release of cytotoxic substances by eosinophils, including eosinophil cationic protein, major basic protein, ribonuclease eosinophil derived neurotoxin, eosinophil peroxidase, and enzymes such as elastase and collagenase. Eosinophils also secrete cytokines...