Thelansis

  Epileptic Encephalopathies (EE) represent a group of devastating epileptic disorders that appear early in life and are characterized by pharmacoresistant generalized or focal seizures, persistent severe electroencephalography (EEG) abnormalities, and cognitive dysfunction. This is most obvious in the idiopathic group. In the symptomatic group, the most common causes are structural, congenital, or acquired, and rarely some metabolic disorders. Clinical and EEG abnormalities persist in some instances and may evolve from one type to another as the child grows older. Various factors trigger and sustain the underlying pathophysiologic process and the ongoing epileptic and epileptiform activity during the most critical periods of brain maturation, perpetuating their deleterious effect on the brain. The chance of a better cognitive outcome improves with early diagnosis and appropriate and effective treatment. Current antiepileptic drugs are, in general, not practical. The goal of treati...