Thelansis

 Giant cell arteritis (GCA), or cranial or temporal arteritis, is a type of immune-mediated inflammation affecting medium to large arteries. It is commonly seen in older adults over 50, with an average age of 70, and primarily affects the cranial arteries, aorta and its branches. The underlying immunopathology involves the activation of T cells and the release of cytokines, including interleukins and gamma interferon. The presence of HLA DR4-01 suggests a role for antigen selection and presentation in its pathogenesis. Clinical manifestations of GCA may include fever, headaches, vision loss, limb claudication, anorexia, fatigue and weight loss. The disease can last months to years and may result in vision loss and thoracic aneurysms. Glucocorticosteroids are the standard treatment, with rapid response seen with a typical initial dose of 60mg prednisone per day. ·        Giant cell arteritis is the most common vasculitis in adulthood, with an annual i...

 Giant cell arteritis (GCA), or cranial or temporal arteritis, is a type of immune-mediated inflammation affecting medium to large arteries. It is commonly seen in older adults over 50, with an average age of 70, and primarily affects the cranial arteries, aorta and its branches. The underlying immunopathology involves the activation of T cells and the release of cytokines, including interleukins and gamma interferon. The presence of HLA DR4-01 suggests a role for antigen selection and presentation in its pathogenesis. Clinical manifestations of GCA may include fever, headaches, vision loss, limb claudication, anorexia, fatigue and weight loss. The disease can last months to years and may result in vision loss and thoracic aneurysms. Glucocorticosteroids are the standard treatment, with rapid response seen with a typical initial dose of 60mg prednisone per day. ·        Giant cell arteritis is the most common vasculitis in adulthood, with an annual i...