Thelansis

  Steroid-refractory acute graft-versus-host disease (SR-aGVHD) is a life-threatening condition when the first-line treatment for acute graft-versus-host disease (aGVHD), systemic corticosteroids, does not work. aGVHD is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT), occurring in 30-50% of patients. It is caused by the donor's immune cells attacking the recipient's tissues. The incidence and severity of aGVHD are influenced by various risk factors. It tends to occur more frequently and with greater severity in cases of alloHCT from HLA-nonidentical or unrelated donors compared to HLA-matched sibling donors. Additional non-HLA risk factors associated with aGVHD encompass older patient or donor age, the utilization of a female donor for a male recipient, the use of peripheral blood as the source of stem cells, the choice of GVHD prophylaxis, and the recipient's seropositivity for cytomegalovirus. The European Society for Blood and Marrow...