Thelansis

  Diphtheria is a bacterial infection caused by Corynebacterium species, primarily Corynebacterium diphtheria, and is characterized by the production and systemic distribution of exotoxin. Exotoxin, a single polypeptide composed of subunits A and B, interferes with protein synthesis through ADP-ribosylation of elongation factor 2. The clinical manifestations of diphtheria vary depending on the anatomic site of infection, the immune status of the host, and exotoxin production. C. diphtheria is a non-encapsulated, non-motile, gram-positive bacillus that forms club-shaped structures arranged in palisade formations. The primary host response to C. diphtheria forms a grey pseudomembrane in the throat and pharynx, a characteristic physical finding of the disease. Other Corynebacterium species, such as Corynebacterium ulcerans, can cause diphtheria. The primary treatment for diphtheria includes the administration of antitoxins and antibiotics (such as erythromycin or penicillin G). The ...

 Diphtheria is a bacterial infection caused by Corynebacterium species, primarily Corynebacterium diphtheria, and is characterized by the production and systemic distribution of exotoxin. Exotoxin, a single polypeptide composed of subunits A and B, interferes with protein synthesis through ADP-ribosylation of elongation factor 2. The clinical manifestations of diphtheria vary depending on the anatomic site of infection, the immune status of the host, and exotoxin production. Corynebacterium diphtheria is a non-encapsulated, non-motile, gram-positive bacillus that forms club-shaped structures arranged in palisade formations. The primary host response to C. diphtheria results in the formation of a gray pseudomembrane in the throat and pharynx, a characteristic physical finding of the disease. Other Corynebacterium species, such as Corynebacterium ulcerans, can cause diphtheria. Diphtheria should be differentiated from other infections with similar presentations, including epiglottiti...