Thelansis

 Lambert-Eaton myasthenic syndrome (LEMS) is a disorder affecting neuromuscular transmission. It was initially observed alongside lung cancer and later in cases without cancer. The syndrome's onset is gradual, with a slow progression of muscle weakness and fatigue, often accompanied by muscle aches and cramps. Typically, this weakness affects symmetrical proximal muscles. The underlying issue in LEMS resides in the presynaptic nerve terminals, disrupting acetylcholine (ACh) release. The diagnosis of Lambert-Eaton myasthenic syndrome can be confirmed by detecting P/Q-type voltage-gated calcium channels (VGCC) in conjunction with electrodiagnostic tests. Distinguishing LEMS from myasthenia gravis (MG) involves looking for specific features such as areflexia, autonomic dysfunction, and post-exercise facilitation, which are unique to LEMS. Additionally, it is crucial to differentiate LEMS from myopathies. The absence of sensory symptoms helps exclude polyneuropathy or polyradiculopathi...