Thelansis

  Cisplatin-induced hearing loss (CIHL) is favored either by pre-existing afflictions like hypoalbuminemia, anemia, renal failure, and noise-induced hearing loss or by risk factors like therapy with loop diuretics, aminoglycoside antibiotics, radiotherapy fields which includes the inner ear, extreme ages (very young or ancient), duration and dose schedule of cisplatin infusion, and genetic factors. Between 11% and 97% of patients treated with cisplatin develop hearing loss, with an average incidence of 62%. Cisplatin-induced tinnitus is not an infrequent occurrence either. Ototoxicity may occur within hours to days after cisplatin administration. Cisplatin inflicts injuries mainly to outer hair cells, progressing from the third to the first row and some extent to the inner hair cells of the organ of Corti in the basal turn of the cochlea followed by alterations in the alterations sensory cells situated in the apex. Cisplatin also targets supporting cells, marginal cells of the stri...