Thelansis

 Limb-Girdle Muscular Dystrophies (LGMD) are a clinically heterogeneous group of disorders presenting a spectrum of disease severity ranging from severe childhood-onset muscular dystrophy to adult-onset dystrophy. LGMDs include both dominant and recessive forms. With the current classification system for LGMDs, 33 recessively (LGMD2) and dominantly (LGMD1) inherited forms of LGMD have now been identified. Interestingly, two LGMD types, with defects in the calpain three and desmin proteins, exist in both recessive and dominant forms. More than 90 percent of all people with the disease have any recessively inherited condition called Type 2 (read more about inheritance patterns under the heading Heredity). LGMD typically manifests itself during childhood or early adulthood. Babies, young children, and older people, on the other hand, can be affected. The severity of the disease varies depending on the subtype. Some subtypes are mild, causing only muscle pain. Others can result in incr...

Limb-Girdle Muscular Dystrophies (LGMD) are a clinically heterogeneous group of disorders presenting a spectrum of disease severity ranging from severe childhood-onset muscular dystrophy to adult-onset dystrophy. LGMDs includes both dominant and recessive forms. With the current classification system for LGMDs, 33 recessively (LGMD2) and dominantly (LGMD1) inherited forms of LGMD have now been identified. Interestingly, two LGMD types, with defects in the calpain three and desmin proteins, exist in both recessive and dominant forms. More than 90 percent of all people with the disease have any recessively inherited conditions called Type 2 (read more about inheritance patterns under the heading Heredity). LGMD typically manifests itself during childhood or early adulthood. Babies, young children, and the elderly, on the other hand, can be affected. The severity of the disease varies depending on the subtype. Some subtypes are mild, causing only muscle pain. Others can result in increase...