Thelansis

  Vaginal cancer is a rare gynecological malignancy, accounting for only 1-2% of all gynecologic neoplasms. Most cases (90%) are squamous cell carcinomas, while 5% are adenocarcinomas. Squamous cell carcinomas spread superficially, with the lungs and liver common sites of distant metastasis. The human papillomavirus (HPV) is a known cause of vaginal cancer, with subtypes HPV 16 and 18 being the primary types responsible. The viral proteins E6 and E7 interfere with critical cell cycle points and contribute to HPV-related neoplasia. HPV infection can lead to the development of high-grade squamous intraepithelial lesions (HGSIL) and carcinoma of the vagina. Primary melanomas of the female reproductive system are rare and aggressive cancers, with the vulva being the most common site, followed by the vagina and, rarely, the cervix. The stage at the time of diagnosis is the most important prognostic factor for vaginal cancer, with 5-year relative survival rates of 96% for stage 0, 64-8...

 Vaginal cancer is a rare gynecological malignancy, accounting for only 1-2% of all gynecologic neoplasms. Most cases (90%) are squamous cell carcinomas, while 5% are adenocarcinomas. Squamous cell carcinomas spread superficially, with the lungs and liver common sites of distant metastasis. Adenocarcinomas have a peak incidence between 17-21 years of age and tend to metastasize to the lung and supraclavicular or pelvic nodes. Clear-cell adenocarcinomas are the least common and are usually associated with adenosis. The human papillomavirus (HPV) is a known cause of vagina carcinoma, with subtypes HPV 16 and 18 being the primary types responsible. HPV infection can lead to the development of high-grade squamous intraepithelial lesions (HGSIL) and carcinoma of the vagina. The viral proteins E6 and E7 interfere with critical cell cycle points and contribute to HPV-related neoplasia. Diethylstilbestrol (DES) exposure in utero has also been linked to vaginal clear cell adenocarcinoma. Pr...