Thelansis

 Huntington's disease, a rare genetic neurodegenerative condition, inflicts devastating consequences on multiple generations of affected families. Its primary hallmark is the progressive deterioration of the putamen, caudate nucleus, and cerebral cortex neurons. The selective breakdown of enkephalin-containing medium spiny neurons within the basal ganglia's indirect pathway is responsible for the characteristic chorea. In contrast, the loss of substance-P-containing medium spiny neurons in the direct pathway leads to dystonia and akinesia. The specific regional pattern of neuronal loss in the cortex and basal ganglia among affected individuals may account for the variations in their clinical presentation. Typically, Huntington's disease emerges between the ages of 30 and 50, with a median life expectancy of approximately 15 years following diagnosis. Although an exceptionally rare juvenile form exists, the usual onset occurs in early middle age, marked by abnormal movements...