Thelansis

 Hepatocellular Carcinoma (HCC) stands out as the predominant form of primary liver cancer, closely linked to the presence of liver cirrhosis. This malignancy typically emerges after prolonged periods of chronic liver disease, during which the liver's regenerative capacity diminishes. The hallmark of cirrhosis is a decline in hepatocyte proliferation, leading to an accumulation of fibrous tissue and the degeneration of liver cells. This pathological process can eventually progress to the development of cancerous nodules. An overwhelming majority, ranging from 70% to 90%, of individuals diagnosed with HCC have a pre-existing history of chronic liver disease and cirrhosis. The key culprits in this scenario include chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV), alcoholic liver disease, and nonalcoholic steatohepatitis (NASH). Notably, hepatitis B virus infection accounts for half of all HCC cases, while hepatitis C virus infection contributes to 25%. Unre...

 Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with liver cirrhosis, which develops following long periods of chronic liver disease. Cirrhosis is characterized by a decrease in hepatocyte proliferation, indicating exhaustion of the regenerative capacity of the liver. It increases fibrous tissue and the destruction of liver cells, which may ultimately lead to the development of cancerous nodules. Approximately 70%–90% of patients with HCC have an established background of chronic liver disease and cirrhosis, including chronic infection with hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease, and nonalcoholic steatohepatitis (NASH). Half of all cases of HCC are associated with hepatitis B virus infection, with a further 25% associated with hepatitis C virus. Unresectable HCC is clinically a heterogeneous group of patients, including those with the intermediate stage (BCLC B) and advanced stage (BCLC C). Thelansis’s “Hepatocell...