Thelansis

 Painful Diabetic Peripheral Neuropathy characteristically presents with a tingling sensation, numbness, burning, excruciating stabbing type of pain, sometimes intractable. It may be associated with paraesthesia and hyperesthesia coupled with deep aching in the feet or hands. Poor glycaemic control is a major risk factor for the development of diabetic neuropathy. It has been observed that an estimated 50% of patients develop Painful Diabetic Peripheral Neuropathy 25 years after the initial diagnosis of diabetes mellitus. The prevalence of PDN ranges from 10% to 20% of patients with diabetes, and in those with diabetic neuropathy, it ranges from 40% to 50%. The underlying mechanism for the generation of pain is hyperexcitability in primary afferent nociceptors, which occurs due to damage to peripheral nerves. This in turn, leads to hyperexcitability in central neurons and the generation of spontaneous impulses within the axon and the dorsal root ganglion of these peripheral nerves....

 Painful Diabetic Peripheral Neuropathy characteristically presents with a tingling sensation, numbness, burning, excruciating stabbing type of pain, sometimes intractable. It may be associated with paraesthesia and hyperesthesia coupled with deep aching in the feet or hands. Poor glycaemic control is a major risk factor for the development of diabetic neuropathy. It has been observed that an estimated 50% of patients develop Painful Diabetic Peripheral Neuropathy 25 years after the initial diagnosis of diabetes mellitus. The prevalence of PDN ranges from 10% to 20% of patients with diabetes, and in those with diabetic neuropathy, it ranges from 40% to 50%. The underlying mechanism for the generation of pain is hyperexcitability in primary afferent nociceptors, which occurs due to damage to peripheral nerves. This in turn, leads to hyperexcitability in central neurons and the generation of spontaneous impulses within the axon and the dorsal root ganglion of these peripheral nerves....

  Painful Diabetic Peripheral Neuropathy characteristically presents with a tingling sensation, numbness, burning, excruciating stabbing type of pain, sometimes intractable and may be associated with paraesthesia and hyperesthesia coupled with deep aching in feet or hands. Poor glycaemic control is a major risk factor for the development of diabetic neuropathy. It has been observed that an estimated 50% of patients develop Painful Diabetic Peripheral Neuropathy 25 years after the initial diagnosis of diabetes mellitus. The prevalence of PDN ranges from 10% to 20% of patients with diabetes and in those with diabetic neuropathy it ranges from 40% to 50%. The underlying mechanism for the generation of pain is hyperexcitability in primary afferent nociceptors, which occurs due to damage to peripheral nerves. This in turn leads to hyperexcitability in central neurons and the generation of spontaneous impulses within the axon as well as the dorsal root ganglion of these peripheral nerves...