Thelansis

 Chronic urticaria (CU) is characterized by recurring hives or welts, which appear at least twice a week for a minimum of 6 weeks. The exact cause of CU is not fully comprehended, but it's believed that the release of histamine due to mast cell degranulation plays a central role. While many CU patients don't have a specific allergen triggering their mast cells, in cases where no underlying cause is identified, the diagnosis is chronic idiopathic urticaria (CIU). CU exhibits various clinical manifestations, primarily marked by the rapid emergence of wheals and angioedema. A wheals typically includes three key elements: (i) a central swelling of variable dimensions, (ii) accompanied by itching or occasionally a burning sensation, and (iii) lasting briefly, usually for 1-24 hours. Angioedema is characterized by sudden, pronounced swelling in the deeper layers of the skin. It can sometimes be painful and takes longer to resolve than wheels (up to 72 hours). Around 40-50% of cases i...