Thelansis

 Primary vitreoretinal lymphoma (PVRL) is a rare type of ocular lymphoid malignancy, and it represents a subset of primary central nervous system lymphoma (PCNSL) and is the most common form of intraocular lymphoma. PVRL typically manifests as a high-grade B-cell malignancy affecting the retina, and it's important to distinguish it from low-grade B-cell lymphomas in the choroid. The underlying pathophysiology of PVRL remains unclear. Diagnosing PVRL is a complex task requiring close collaboration between ophthalmologists and cytologists. Due to their scarcity and the fragile nature of lymphoma cells in the vitreous, they may not always be readily identifiable. A combination of clinical ophthalmological examination, interleukin levels, molecular biology, and imaging techniques is employed to support the diagnosis of PVRL. PVRL typically afflicts immunocompetent adults in their 50s, with a slight preference for females and no specific racial predisposition. While PVRL is predominantl...

  Primary vitreoretinal lymphoma (PVRL) is a rare B-cell intraocular malignancy, commonly considered a subset of primary central nervous system (CNS) lymphoma. Brain dissemination occurs in 60–90% of patients, and it is the cause of the high mortality and morbidity of the disease. PVRL involves the vitreous, the retina, and the retinal pigment epithelium (RPE). According to the literature, around 15–20% of patients with primary central nervous system lymphoma (PCNSL) will develop PVRL later. The majority of PVRL is of B-cell origin. However, T-cell lymphomas and T-cell-rich lymphomas can also develop within the eye. PVRL has an approximate incidence in ~20% of patients with PCNSL and 0.03 to 0.1 cases per 100,000 people per year in the US. PVRL usually affects adults in the fifth-sixth decades of life. Thelansis’s “Primary Vitreoretinal Lymphoma (PVRL) Market Outlook, Epidemiology, Competitive Landscape , and Market Forecast Report – 2021 To 2032" covers disease ov...