Thelansis

 Autosomal recessive hereditary hemochromatosis disrupts the body's iron regulation, leading to iron overload. This condition results in restrictive cardiomyopathy, diastolic dysfunction, heart failure, dysrhythmias, and conduction defects, potentially causing atrioventricular block, bradyarrhythmias, tachyarrhythmias, and sudden cardiac death. Iron-overload cardiomyopathy can be reversed if treatment is initiated before overt heart failure. Types 2, 3, and 4 of hereditary hemochromatosis have a global presence, while type 1 primarily affects those of northern European ancestry. Hemochromatosis affects various organs, including the liver, pancreas, heart, thyroid, joints, skin, gonads, and pituitary. Excessive alcohol consumption and viral hepatitis exacerbate the impact of hemochromatosis on the liver and pancreas. The leading cause of hemochromatosis is a hereditary autosomal recessive condition with variable penetrance, termed primary hemochromatosis. Homozygotes with a mutation...