Thelansis

  Goodpasture’s syndrome (GS) is a rare, life-threatening, small vessel vasculitis that is mediated by circulating anti-glomerular basement membrane (anti-GBM) autoantibodies against the NC1 domain of the alpha 3 chain of type IV collagen, targeting capillaries of the kidneys and lungs. It is considered as one of the organ-specific autoimmune diseases that typically presents as rapidly progressive glomerulonephritis (RPGN), accompanied by alveolar hemorrhage with pathology characterized by crescentic glomerulonephritis with classic linear polyclonal immunoglobulin (Ig) G deposits on immunofluorescence staining of the GBM on analysis of kidney biopsy samples. Without prompt diagnosis and treatment, patients with GS can develop organ failure, resulting in significant morbidities and mortality. Patient characteristics included age, sex, race, year of hospitalization, smoking, hemoptysis, and the presence of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, which consi...