Thelansis

  Retinoblastoma is a rare tumor but is childhood’s most common eye tumor. Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The prognosis is excellent for long-term survival when it remains localized to the eye, whereas metastatic retinoblastoma is an aggressive malignant neoplasm with poor survival rates. Through this experience, retinoblastoma has been found to have a vital genetic component. Some case...