Thelansis

 Limb-Girdle Muscular Dystrophies (LGMD) are a clinically heterogeneous group of disorders presenting a spectrum of disease severity ranging from severe childhood-onset muscular dystrophy to adult-onset dystrophy. LGMDs include both dominant and recessive forms. With the current classification system for LGMDs, 33 recessively (LGMD2) and dominantly (LGMD1) inherited forms of LGMD have now been identified. Interestingly, two LGMD types, with defects in the calpain three and desmin proteins, exist in both recessive and dominant forms. More than 90 percent of all people with the disease have any recessively inherited condition called Type 2 (read more about inheritance patterns under the heading Heredity). LGMD typically manifests itself during childhood or early adulthood. Babies, young children, and older people, on the other hand, can be affected. The severity of the disease varies depending on the subtype. Some subtypes are mild, causing only muscle pain. Others can result in incr...

  Limb-Girdle Muscular Dystrophy (LGMD) is a common chronic multifactorial ocular surface condition characterised by a failure to produce high-quality or sufficient amounts of tears to moisturise the eyes. Ageing, female sex, low humidity environments, systemic medications, and autoimmune disorders are all common risk factors for this syndrome. DED is classified as "dry eye with reduced tear production (aqueous deficient)" or "dry eye with increased evaporation of the tear film (hyper-evaporative type). Although 10% of people have aqueous deficient DED, more than 80% have hyper-evaporative type related to meibomian gland dysfunction (MGD) or a combination of the two. DED can significantly impact vision and quality of life because symptoms frequently interfere with daily activities such as writing, reading, or working on video display monitors. In the USA, the prevalence of Limb-Girdle Muscular Dystrophy (LGMD) ranges from 5% to 7% in the adult population. The...