Thelansis

  Bronchopulmonary dysplasia (BPD) is defined as the total duration of oxygen supplementation, positive pressure required, gestational age and oxygen dependency at 36 weeks postmenstrual age. Mechanical ventilation and reactive oxygen species injury to premature lungs in the presence of antenatal factors predisposing the lungs to bronchopulmonary dysplasia form from the basis of the pathogenesis in preterm neonates; leading to an exaggerated inflammatory response with an increase in proinflammatory cytokines such as IL-6 and IL-8, TNF-alpha, and angiogenic factors resulting in aberrant tissue repair and arrest in lung development. Bronchopulmonary Dysplasia can classify its severity as mild, a fraction of inspired oxygen (FiO2) =21%; moderate FiO2<30%, and severe, with FiO2 ≥ 30% or positive pressure support. The risk factor includes prematurity and low birth weight. The global incidence of Bronchopulmonary dysplasia (BPD) ranged from 10% to 89% (10% to 73% in Europe, 1...