Thelansis

Progressive multifocal leukoencephalopathy (PML) is a rare, fatal demyelinating disease of the central nervous system (CNS) caused by the JC virus (JCV) that occurs in patients with weakened immune systems. Initial infection with JC virus (JCV) through ingestion or inhalation of virion particles might lead to subacute infection and stimulation of antiviral antibodies. JCV can infect the uroepithelium of the kidney and establish a persistent or latent infection and might escape into the peripheral circulation, spreading virions into lymphoid tissues and showing a latent infection that can be reactivated at times of immune suppression or modulation. PML develops in patients with underlying neoplastic diseases, mostly lymphoproliferative diseases, and in patients with organ transplants who have undergone immune suppression for graft protection. JCV has a narrow cellular host range and a variable effect on the organs it infects. Infection in human endothelial cells in the kidney and in cel...