Thelansis

  Persistent corneal epithelial defects (PEDs or PCEDs) result from the failure of rapid re-epithelialization and closure within 10-14 days after a corneal injury, even with standard supportive treatment. Disruptions in the cornea's protective epithelial and stromal layers can render the eye susceptible to infection, stromal ulceration, perforation, scarring, and significant vision loss. The multi-layered corneal epithelium is a protective barrier to infectious agents via tight junctions between neighboring cells. It maintains its smooth optical surface by constantly regenerating cells in the basal cell layer. Disruptions in this protective layer can render the eye susceptible to infection, stromal ulceration, perforation, scarring, and decreased visual acuity. The annual incidence of PED ranges between 25 to 38 cases per 100,000 population in the USA.   The competitive landscape of Persistent Corneal Epithelial Defect (PCED)  includes country-specific approved and ...