Thelansis

Hemophilia A is an x-linked genetic disorder characterized by the deficiency of factor VIII. the liver is the predominant source of factor VIII, which is then secreted and circulated in the bloodstream in an inactive form in a complex with von Willebrand factor. Several other tissues produce factor VIII, including the endothelium. Factor IX is produced entirely by the liver. Chronic hemarthroses are one of the most common long-term complications of hemophilia. Intra-articular bleeding may resolve on its own or with treatment in an acute case. However, many patients will experience recurrent bleeding and develop single or multiple target joints that are often painful and restrict their daily activity. Common sites are the knee, elbow, and ankle. Over time, chronic synovitis and chronic hemarthroses can result in degenerative joint disease, osteoarthritis, and osteophyte formation. In the United States, most people with hemophilia are diagnosed at a very young age, Hemophilia A affects 1...