Thelansis

 Persistent corneal epithelial defects (PEDs or PCEDs) arise from the inability to rapidly regenerate and close the corneal surface within 10-14 days following injury, despite standard supportive therapy. Disruptions in the corneal epithelium and stroma's protective layers can lead to severe consequences, including infection, stromal ulceration, perforation, scarring, and significant vision impairment. The multilayered corneal epithelium, held together by tight junctions, is a crucial barrier against infectious agents while maintaining optical smoothness through constant cell regeneration in the basal layer. Various factors contribute to the development of PED, including dry eyes, limbal stem cell deficiency, diabetes mellitus, and neurotrophic issues. Conventional treatments involve frequent application of artificial tears, protective eyewear, and punctal occlusion. However, artificial tears lack essential components like epidermal growth factor (EGF), vitamin A, and transforming ...

 Persistent corneal epithelial defects (PEDs or PCEDs) are caused by the failure of rapid re-epithelialization and closure following a corneal injury within 10-14 days, even with standard supportive treatment. Infection, stromal ulceration, perforation, scarring, and significant vision loss can result from disruptions in the cornea's protective epithelial and stromal layers. Through tight junctions between neighbouring cells, the multilayered corneal epithelium acts as a protective barrier to infectious agents. It keeps its optical surface smooth by constantly regenerating cells in the basal cell layer. Infection, stromal ulceration, scarring, perforation, and decreased visual acuity can all result from disruptions in this protective layer. ·        The annual incidence of Persistent Corneal Epithelial Defect (PCED) ranges from 25 to 38 cases per 100,000 population in the USA. Thelansis’s “Persistent Corneal Epithelial Defect (PCED) Market Outlook,...