Thelansis

  Homologous recombination deficiency (HRD) is a cellular phenotype characterized by the inability to repair double-strand DNA effectively breaks through the homologous recombination repair (HRR) pathway. This condition can arise from mutations in BRCA1, BRCA2, and other HRR pathway genes. Various tumor types, including breast, ovarian, prostate, and pancreatic cancers, have been linked to deficiencies in the HRR pathway. Cells lacking functional HRR must rely on alternative, less precise DNA repair pathways. These pathways can lead to widespread genomic alterations, including insertions, deletions, copy number changes, and structural rearrangements. Molecular techniques can detect these genomic scars, which are indicative of HRD. Alterations in these genes have been identified as potential "causes" of HRD, encompassing genetic and epigenetic events. HRR is a vital DNA repair mechanism that corrects various types of DNA damage, particularly double-strand breaks and interstr...

  Homologous recombination deficiency (HRD) is a cellular phenotype characterized by the inability to repair double-strand DNA effectively breaks through the homologous recombination repair (HRR) pathway. This condition can arise from mutations in BRCA1, BRCA2, and other HRR pathway genes. Various tumor types, including breast, ovarian, prostate, and pancreatic cancers, have been linked to deficiencies in the HRR pathway. Cells lacking functional HRR must rely on alternative, less precise DNA repair pathways. These pathways can lead to widespread genomic alterations, including insertions, deletions, copy number changes, and structural rearrangements. Molecular techniques can detect these genomic scars, which are indicative of HRD. Alterations in these genes have been identified as potential "causes" of HRD, encompassing genetic and epigenetic events. HRR is a vital DNA repair mechanism that corrects various types of DNA damage, particularly double-strand breaks and interstr...