Calciphylaxis – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Calciphylaxis, or calcific uremic arteriolopathy (CUA), is a rare condition characterized by subcutaneous vascular calcification and cutaneous necrosis. It is frequently observed in individuals with renal failure. This condition is alternatively referred to as metastatic calcinosis cutis and necrotizing or calcifying panniculitis. The precise underlying mechanisms of calciphylaxis remain unclear, which has led to a lack of well-established therapies for its treatment. During the disease, severe pain is a common feature, often accompanied by tactile hypersensitivity, although the pain intensity may vary. Initial skin manifestations can manifest as induration, plaques, nodules, livedo, or purpura. Patients usually exhibit multiple bilateral lesions, with the surrounding skin developing a leather-like texture. These initial lesions progress rapidly into stellate ulcers with a foul odor and the formation of black eschars. Sepsis resulting from these wounds is the leading cause of deat...