Thelansis

  BK polyomavirus (BKV) belongs to the Polyomaviridae family of double-stranded DNA (dsDNA) viruses. BKV is a common childhood infection that rarely leads to severe clinical consequences, and over 80% of adults have antibodies against BKV. BKV remains latent after the primary infection in healthy individuals and does not cause significant morbidity. However, in some immunosuppressed individuals, such as those with HIV infection or who have undergone transplantation, BKV may reactivate and cause clinical complications. Among these patients, kidney transplant recipients (KTRs) are the most commonly affected, with a median of 19.5% developing BK viremia after transplantation. BKV enters the bloodstream through infected tonsillar tissue, infecting peripheral blood mononuclear cells and spreading to secondary sites of infection, such as the kidney. BKV DNA has been detected in leukocytes, lymph nodes, and the brain. The mechanisms underlying viral persistence and reactivation upon imm...

BK polyomavirus (BKV) belongs to the Polyomaviridae family of double-stranded DNA (dsDNA) viruses. BKV is a common childhood infection that rarely leads to severe clinical consequences, and over 80% of adults have antibodies against BKV. BKV remains latent after the primary infection in healthy individuals and does not cause significant morbidity. However, in some immunosuppressed individuals, such as those with HIV infection or who have undergone transplantation, BKV may reactivate and cause clinical complications. Among these patients, kidney transplant recipients (KTRs) are the most commonly affected, with a median of 19.5% developing BK viremia after transplantation. BKV enters the bloodstream through infected tonsillar tissue, infecting peripheral blood mononuclear cells and spreading to secondary sites of infection, such as the kidney. BKV DNA has been detected in leukocytes, lymph nodes, and the brain. The mechanisms underlying viral persistence and reactivation upon immunosuppr...