Thelansis

  Lipoprotein disorders are clinically significant due to their role in atherogenesis and the associated risk of atherosclerotic cardiovascular disease (ASCVD). In patients with established ASCVD (secondary prevention), cholesterol-lowering interventions consistently reduce cardiovascular mortality and events across genders and age groups. Lipoproteins, composed of lipids and proteins, transport cholesterol, triglycerides, and fat-soluble vitamins in plasma to various organs. High cholesterol is defined as LDL-cholesterol levels exceeding 190 mg/dL, greater than 160 mg/dL with one significant risk factor, or greater than 130 mg/dL with two cardiovascular risk factors. Key risk factors include age (≥45 years for males, ≥55 years for females), a positive family history of premature ASCVD (onset before 55 years in males and 65 years in females), hypertension, diabetes, smoking, and low HDL-cholesterol levels (<40 mg/dL in males and <55 mg/dL in females). Familial hypercholeste...