Thelansis

  Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common side effects caused by antineoplastic agents, with a prevalence ranging from 19% to over 85%. CIPN is predominantly sensory neuropathy accompanied by motor and autonomic changes of varying intensity and duration. Because of its high prevalence among cancer patients, CIPN constitutes a significant problem for both cancer patients and survivors and their health care providers, mainly because, at the moment, there is no single effective method of preventing CIPN. Central sensitization plays a role in pain, particularly in neuropathic pain. The literature suggested the involvement of a wide array of neurons, ion channels, signaling pathways, molecules, and non-neuronal cells in central sensitization. Damage to peripheral nerves (particularly C-fibers) causes spontaneous activity, which alters secondary order neurons in the spinal dorsal horn and results in hyper-excitability via various molecular changes. ...