Thelansis

  Follicular lymphoma (FL), commonly referred to as indolent lymphoma, is the second most common type of non-Hodgkin lymphoma (NHL). Advanced stage disease is considered incurable and is characterized by a prolonged relapsing/remitting course. A significant minority have less favorable outcomes, particularly those with transformed or early progressive disease. The introduction of anti-CD20 monoclonal antibodies (mAb) such as rituximab, and, more recently the type II anti-CD20 mAb, obinutuzumab, have revolutionized the management of FL and it is likely that anti-CD20 antibodies will remain at the forefront of the FL treatment armamentarium. But more recent insights demonstrating the intricate relationship between the FL tumor cell and its distinct immune microenvironment have led to a rapid accumulation of novel and innovative targeted therapies that harness the power of the immune system to attack the malignant cell. FL affects approximately 3.7 in 10,000 individuals in the Europ...