Thelansis

 Aplastic anemia is a syndrome characterized by chronic primary hematopoietic failure due to injury resulting in reduced or absent hematopoietic precursors in the bone marrow, leading to pancytopenia. The onset occurs over weeks or months after exposure to a toxic agent, although it can occasionally be acute. Its symptoms include weakness, easy fatigability, ecchymosis, petechiae, and bleeding from the gums into the conjunctivae. Fanconi anemia is the most prevalent hereditary cause, presenting in the late first decade with pancytopenia, organ hypoplasia, and bone defects such as abnormal radii, absent thumbs, and short stature. The most frequent etiology is idiopathic, accounting for 65% of cases. Seronegative hepatitis accounts for 5-10% of cases, while telomerase defects are found in 5-10% of adult-onset aplastic anemia. Patients who undergo bone marrow transplantation from a suitable donor have a five-year survival rate of over 75%. Most untreated patients die within one year d...