Thelansis

  Granulomatosis with Polyangiitis (GPA) is a systemic ANCA-associated granulomatous vasculitis whose lesions mainly affect the respiratory tract and kidneys. It can occur at any age with a peak at 65-74 years of age. The disease can present with non-specific constitutional symptoms: malaise, myalgia, arthralgia, anorexia, weight loss. It affects different organs, airways, and renal involvement being the most frequent. The involvement of the upper airway is the most common and characteristic (70-100% at the time of diagnosis), mainly at the nasal and sinus levels, and may manifest with nasal discharge, epistaxis, nasal ulcers, perforation of the nasal septum, granulomatous lesions or destruction of facial cartilage with deformation of the nasal bridge, sinus or parasinus inflammation. ·        The annual incidence cases range between 5 to 10 cases per MN population and the prevalence cases range between 56  to 89 cases per million. The competi...