Thelansis

  CHAPLE disease, also known as CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy, is a rare, inherited disorder affecting the immune and digestive systems. It is caused by a genetic mutation that leads to a deficiency of the complement regulatory protein CD55. CD55 is a protein that helps to protect the body from infection by preventing the activation of the complement system, a part of the immune system that helps to fight infection. When CD55 is deficient, the complement system can become overactivated, leading to various problems, including: protein-losing enteropathy, thrombosis, and immune deficiency. The symptoms of CHAPLE disease can vary from person to person and can start at any age. Some people may have mild symptoms, while others may have more severe symptoms. The most common symptoms include diarrhea, weight loss, edema (swelling), abdominal pain, fever, fatigue, recurrent infections, easy bruising, nosebleeds,...

 CHAPLE disease, also known as CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy, is a rare, inherited disorder affecting the immune and digestive systems. It is caused by a genetic mutation that leads to a deficiency of the complement regulatory protein CD55. CD55 is a protein that helps to protect the body from infection by preventing the activation of the complement system, a part of the immune system that helps to fight infection. When CD55 is deficient, the complement system can become overactivated, leading to various problems, including: protein-losing enteropathy, thrombosis, and immune deficiency. The symptoms of CHAPLE disease can vary from person to person and can start at any age. Some people may have mild symptoms, while others may have more severe symptoms. The most common symptoms include diarrhea, weight loss, edema (swelling), abdominal pain, fever, fatigue, recurrent infections, easy bruising, nosebleeds, an...