Thelansis

  Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of broad electroclinical syndromes characterized by epilepsy, developmental delay or regression or intellectual disability, an abnormal EEG, and other possible neurological or systemic manifestations. DEEs are classically considered pediatric disorders as most of the phenotypes are identified in children. Clinical data suggest that neurodevelopmental impairment in classical epileptic encephalopathies starts before epilepsy onset and progresses after epilepsy remission; DEEs consider that epileptic activity in classical epileptic encephalopathies plays only a partial or limited role in the neurodevelopment of the patient. It is established that epilepsy is more an epiphenomenon of the etiological process and the abnormal neurodevelopmental trajectory, which plays the leading role in the pathophysiological process. In most cases, patients remain undiagnosed due to insufficient genetic testing; an est

Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of broad electroclinical syndromes characterised by epilepsy, developmental delay or regression or intellectual disability, an abnormal EEG, and other possible neurological or systemic manifestations. DEEs are classically considered pediatric disorders as most of the phenotypes are identified in children. Clinical data suggest that neurodevelopmental impairment in classical epileptic encephalopathies starts before epilepsy onset and progresses after epilepsy remission; DEEs consider that epileptic activity in classical epileptic encephalopathies plays only a partial or limited role in the neurodevelopment of the patient. It is established that epilepsy is more an epiphenomenon of the etiological process and the abnormal neurodevelopmental trajectory, which plays the leading role in the pathophysiological process. In most cases, patients remain undiagnosed due to insufficient genetic testing; an estimated 50%