Thelansis

  IgG4-related disease (IgG4-RD) is a multi-organ disorder that presents clinical and histopathological features similar to malignant, infectious, and inflammatory conditions. The disease exhibits a tumefactive clinical presentation consistent across multiple organ systems, except for the aorta, meninges, and bile ducts, in which the sclerosing nature of the disease predominates. The most common presentation is diffuse, or focal pseudotumoral swelling of an organ discovered clinically or radiologically, along with enlarged lymph nodes that are often painless and hard. The onset of the disease is usually subacute and asymptomatic, and common manifestations include fever, weight loss, or increased inflammatory parameters, which are present in only a minority of patients. The incidence of extrapancreatic manifestations, such as mediastinal or abdominal lymphadenopathy and involvement of the lacrimal or salivary glands, kidneys, lungs, and retroperitoneum, varies, with pancreatitis b...

IgG4-related disease (IgG4-RD) is a multi-organ disorder that presents clinical and histopathological features similar to malignant, infectious, and inflammatory conditions. The disease exhibits a tumefactive clinical presentation consistent across multiple organ systems, except for the aorta, meninges, and bile ducts, in which the sclerosing nature of the disease predominates. The most common presentation is diffuse, or focal pseudotumoral swelling of an organ discovered clinically or radiologically, along with enlarged lymph nodes that are often painless and hard. The onset of the disease is usually subacute and asymptomatic, and common manifestations include fever, weight loss, or increased inflammatory parameters, which are present in only a minority of patients. The incidence of extrapancreatic manifestations, such as mediastinal or abdominal lymphadenopathy and involvement of the lacrimal or salivary glands, kidneys, lungs, and retroperitoneum, varies, with pancreatitis being the...