Thelansis

 Hutchinson-Gilford progeria syndrome (HGPS), also called progeria, is a rare, fatal genetic childhood condition with striking features resembling premature aging. Children with progeria usually have a regular appearance in early infancy. At approximately nine to 24 months, affected children experience profound growth delays, resulting in short stature and low weight. Characteristic facial features include a head that is disproportionately large for the face, narrow nasal ridge, narrow nasal tip, thin vermilion of the upper and lower lips, small mouth, and retro- and micrognathia. Standard features include loss of subcutaneous fat, delayed eruption and loss of primary teeth, abnormal skin with small outpouchings over the abdomen and upper thighs, alopecia, nail dystrophy, coxa valga, and progressive joint contractures. Later findings include low-frequency conductive hearing loss, dental crowding, and partial lack of secondary tooth eruption. Motor and mental development are typical...

 Hutchinson-Gilford Progeria Syndrome (HGPS) is a genetic condition that causes ageing to appear suddenly and dramatically in childhood. Affected children appear normal at birth and early childhood but grow more slowly than other children and do not gain weight at the expected rate (failure to thrive). Mutations in the LMNA gene cause Hutchinson-Gilford progeria syndrome. The LMNA gene provides instructions for making a protein known as lamin A. ·        The prevalence of Hutchinson-Gilford Progeria Syndrome (HGPS) is approximately 1 in 20 million, so at any given time, approximately 400 children are living with progeria worldwide. As of December 2020, the Progeria Research Foundation International Progeria Registry has identified a total of 131 children and young adults living with progeria worldwide, including 20 living in the US. Thelansis’s “Hutchinson-Gilford Progeria Syndrome (HGPS) Market Outlook, Epidemiology, Competitive Landscape , and Ma...