Thelansis

 Medulloblastoma, an embryonal lesion believed to originate from progenitor cell populations during early brain development, is the predominant malignant brain tumor in children. It constitutes approximately 20% of all pediatric brain tumors and 63% of intracranial embryonal tumors. Primary risk factors for medulloblastoma development involve hereditary cancer predisposition syndromes, with germline mutations in WNT signaling pathway genes, like APC mutations in Turcot syndrome, predisposing individuals to WNT medulloblastoma. The WNT subgroup of medulloblastoma represents around 10% of all medulloblastoma cases. In children under four, medulloblastoma ranks as the most common malignant brain tumor, while in those aged five to fourteen, it becomes the second most common. The median age for diagnosis is seven years old, with children under ten constituting over 70% of all pediatric medulloblastoma cases. ·        Medulloblastoma incidence ranges from ...

  Medulloblastoma is the most common type of malignant brain tumour in children. It is an embryonal lesion that is thought to develop from progenitor cell populations present during early brain development. Medulloblastoma accounts for about 20% of all paediatric brain tumours and 63% of intracranial embryonal tumours. Hereditary cancer predisposition syndromes are primary risk factors for the development of medulloblastoma. Germline mutations in WNT signalling pathway genes, such as APC mutations, which occur in Turcot syndrome, can predispose to WNT medulloblastoma. WNT subgroup medulloblastoma accounts for approximately 10% of all medulloblastoma. Medulloblastoma is the most common malignant brain tumour in children under the age of four and the second most common in children aged five to fourteen. The median age of diagnosis is seven, with children under the age of ten accounting for more than 70% of all pediatric medulloblastomas diagnosed. Medulloblastoma incidence ranges...