Thelansis

Familial adenomatous polyposis (FAP) is an inherited condition that primarily affects the gastrointestinal tract. This condition causes hundreds or thousands of polyps to form inside the colon and rectum. This condition is also known as hereditary polyposis of the colorectum, Gardner's syndrome, and familial polyposis. Nearly 100% progression to colorectal cancer (CRC) by the age of 35–40 yr and a heightened risk of various other malignancies. Familial adenomatous polyposis (FAP) is a highly penetrant autosomal-dominant disorder caused by a germline mutation in the adenomatous polyposis coli (APC) gene, located on chromosome 5q21. Over 700 different disease-causing APC mutations have been reported to date. However, the most common germline mutation involves the introduction of a premature stop codon, either by a nonsense mutation (30%), frameshift mutation (68%), or large deletion (2%), leading to truncation of the protein product in the C-terminal region. ·     ...

  Familial adenomatous polyposis (FAP) is an inherited condition that primarily affects the gastrointestinal tract. This condition causes hundreds or thousands of polyps to form inside the colon and rectum. This condition is also known as hereditary polyposis of the colorectum, Gardner's syndrome, and familial polyposis. Nearly 100% progression to colorectal cancer (CRC) by the age of 35–40 yr and a heightened risk of various other malignancies. Familial adenomatous polyposis (FAP) is a highly penetrant autosomal-dominant disorder caused by a germline mutation in the adenomatous polyposis coli (APC) gene chromosome 5q21. Over 700 different disease-causing APC mutations have been reported to date. However, the most common germline mutation involves the introduction of a premature stop codon, either by a nonsense mutation (30%), frameshift mutation (68%), or large deletion (2%), leading to truncation of the protein product in the C-terminal region.   The birth frequency of F...