Thelansis

  Laryngeal cancer (LC) represents one-third of all head and neck cancers and is a significant cause of morbidity and mortality. They can involve different subsites of the larynx, with varying implications in symptomatic presentation, patterns of spread, and treatment paradigms. Early-stage disease is highly curable with surgical or radiation monotherapy, often larynx-preserving. In contrast, the late-stage disease has a worse outcome, warrants multimodal therapy, and is less often larynx-preserving. The laryngeal cancers vast majority are well-differentiated squamous cell carcinoma. A minority of cases show squamous cell variants, including neuroendocrine carcinoma, sarcomatoid carcinoma, and verrucous carcinoma. Historically, verrucous and sarcomatoid carcinomas were thought to be radioresistant, though recent experience contradicts this notion. Spread patterns depend on the location of the primary mass and the inherent lymphatic supply at that location. Laryngeal cancers are d...

 Laryngeal cancer (LC) represents one-third of all head and neck cancers and is a significant cause of morbidity and mortality. They can involve different subsites of the larynx, with varying implications in symptomatic presentation, patterns of spread, and treatment paradigms. Early-stage disease is highly curable with surgical or radiation monotherapy, often larynx-preserving. In contrast, the late-stage disease has a worse outcome, warrants multimodal therapy, and is less often larynx-preserving. The laryngeal cancers vast majority are well-differentiated squamous cell carcinoma. A minority of cases show squamous cell variants, including neuroendocrine carcinoma, sarcomatoid carcinoma, and verrucous carcinoma. Historically, verrucous and sarcomatoid carcinomas were thought to be radioresistant, though recent experience contradicts this notion. Spread patterns depend on the location of the primary mass and the inherent lymphatic supply at that location. Laryngeal cancers are divi...